Hyaluronic acid fillers, A Synopsis on safety of HA fillers

April 20, 2023

Hyaluronic acid fillers, A Synopsis on safety of HA fillers


Here is a synopsis of the literature review from the NIH:


Hyaluronic acid fillers with cohesive polydensified matrix for soft-tissue augmentation and rejuvenation: a literature review

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What are HA fillers? You have heard of them. Some examples are Belotero, Restylane, Juvederm. 

With a skilled injector, the most Common Side effects reported immediately and within 6 months: "The most common adverse effects were mild-to-moderate redness, swelling, and bruising, most of which were temporary. There were no reports of Tyndall effect, nodules, granulomas, or tissue necrosis."


In Summation and important clinical points:

  • " Clinical evidence indicates sustainable esthetic effects, good safety profile, and long-term tolerability of the Belotero® fillers, particularly Belotero® Basic/Balance and Intense."
  • "In the 4-week follow-up, pain recorded immediately after injection was lower with Belotero® Basic/Balance than with Restylane® (both being lidocaine-free)."
  • " Belotero® was also found to be safe in Fitzpatrick skin types "
  • " No major differences in safety profiles were observed in head-to-head comparisons between Belotero® Basic/Balance and collagen,36 and other HA fillers (Restylane® or Juvéderm®) " 
  • " The authors concluded that Belotero® has little potential for immunogenic reactions. "

If you would like to read the full study, please click here

Overall, the safety of HA fillers is minimal if performed by a skilled injector


Prasetyo, A. D., Prager, W., Rubin, M. G., Moretti, E. A., & Nikolis, A. (2016). Hyaluronic acid fillers with cohesive polydensified matrix for soft-tissue augmentation and rejuvenation: a literature review. Clinical, cosmetic and investigational dermatology, 9, 257–280. https://doi.org/10.2147/CCID.S106551 

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Injectable peptides for anti-aging?

January 10, 2023
First, lets break down what a peptide is-- Peptides are chains of amino acids. Amino acids are the building blocks of proteins in the body. Proteins are needed for a multitude of reasons. In particular, to help build and repair damaged cells.