Patients considering BHRT should discuss the potential benefits and risks with their healthcare provider to determine the most appropriate hormone therapy plan. A thorough evaluation by the healthcare professionals at 716ology can help determine the most appropriate treatment for patients throughout Orchard Park, West Seneca, Hamburg, Buffalo, NY, and the surrounding WNY communities.


Contact us today to learn more about the benefits Bioidentical hormone replacement therapy can provide you or to book an appointment with a member of our medical team!

References Addressing Safety:

1. Chlebowski, A et al. Menopausal Hormone Therapy Influence on Breast Cancer Outcomes in the Women’s Health Initiative. J Natl Compr Canc Netw, 2015 Jul;13(7):917-24.

2. Pinkerton, JV. Reassuring data regarding the use of estrogen therapy at the menopause. Menopause: The Journal of The North American Menopause Society, 2022, Vol. 29, No. 9, pp. 1001-1004.

3. Lobo RA, et al. Back to the future: Hormone replacement therapy as part of a prevention strategy for women at the onset of menopause, Atherosclerosis, 2016 Nov;254:282-290.

4. Turner R, Kerber IJ. A theory of eu-estrogenemia: a unifying concept. Menopause, Vol. 24, No. 9, pp. 1086-1097.

5. Kim, YJ et al. Association between menopausal hormone therapy and risk of neurodegenerative diseases: Implications for precision

hormone therapy. Alzheimer’s Dement. 2021;7:e12174.

6. Blakemore J, Naftolin F. Aromatase: Contributions to Physiology and Disease in Women & Men. Physiology, 2016 June;(31) 258-269.

7. Zhao H, et al. Aromatase Expression and Regulation in Breast and Endometrial cancer. J Molecul Endocrinology, 2016 Jul;(1):R19-33.

8. Glaser RL, Dimitrakakis C. Beneficial Effects of T Therapy in Women by Menopause Rating Scale. Maturitas. 2011 Apr;68(4) 355-61.

9. Glaser RL, Dimitrakakis C. Testosterone Therapy in Women: Myths and Misconceptions. Maturitas, 2013 Mar;74(3):230-4.

10. NotelovitzM.Androgeneffectsonboneandmuscle.FertilityandSterility.2002Apr;77Suppl4:S34-41.

11. Savvas M, et al. Increase in bone mass after one year of estradiol and testosterone implants in post-menopausal women who

previously received long-term oral estrogens. Br J Obstet Gynecol. 1992, Sep;99(9):757-60.

12. DavisSR,Wahlin-JacobsenS.Testosteroneinwomen—theclinicalsignificance.LancetDiabetesEndocrinol.2015;3:980–92.

13. Turner A et al. Testosterone increases bone mineral density in female to male transsexuals: a case series of 15 subjects. Clin

Endocrinol (Oxf). 2004 November ; 61(5): 560–566.

14. VEBiancheVE.TheAnti-InflammatoryEffectsofTestosterone.TheJournaloftheEndocrineSociety,2018Oct22;3(1):91-107.

15. Bialek M. Neuroprotective Role of Testosterone in the Nervous System. Pol J Pharmacol, 2004, Sep-Oct;(5): 509-18.

16. BrittoR,etal.ImprovementoflipidprofileinpostmenopausalwomenusingEandTimplants.GynecEndocr,2012;28(10):767-769.

17. Worboys S, et al. Evidence That Parenteral [pellet implant] Testosterone Therapy May Improve Vasodilation in Postmenopausal Women Receiving Estrogen, Journal of Clinical Endocrinology & Metabolism, Volume 86, Issue 1, Jan 2001, 158–161.

18. Hofling, M, et al. Testosterone inhibits estrogen/progesterone-induced breast cell proliferation in postmenopausal women.

Menopause, The Journal of the North American Menopause Society, 2007, Vol 14(2)183-190.

19. Glaser RL, Dimitrakakis C. Reduced Breast Cancer Incidence in Women Treated with Subcutaneous Testosterone, or Testosterone with Anastrozole: A prospective, observational study. Maturitas 76 (2013) 342-349.

20. Glaser RL, Dimitrakakis C. Incidence of invasive breast cancer in women treated with testosterone implants: a prospective 10-year cohort study. Glaser et al. BMC Cancer (2019) 19:1271.

21. BoniC,etal.TherapeuticActivityofTestosteroneinMetastaticBreastCancer.AnticancerResearch,2014;34:1287-1290.

22. Traish AM, Gooren L. Safety of physiological testosterone therapy in women: lessons from female-to-male transsexuals (FMT)

treated with pharmacological testosterone therapy. J Sex Med. 2010 Nov;7(11):3758-64.